Table 2 The association of early neurological wake-up test with outcomes in the matched cohort

Primary outcome

 28-day mortality^b, n (%)

131 (37.2)

87 (24.7)

0.55 (0.42–0.72)

 < 0.001

0.57 (0.44–0.76)

 < 0.001

Secondary outcomes

 In-hospital mortality^c, n (%)

135 (38.4)

90 (25.6)

0.55 (0.40–0.76)

 < 0.001

0.54 (0.38–0.77)

0.001

 Discharge-home^c, n (%)

60 (17.0)

85 (24.1)

1.55 (1.07–2.24)

0.02

1.83 (1.19–2.83)

0.006

 Ventilator associated pneumonia^c, n (%)

31 (8.8)

44 (12.5)

1.48 (0.91–2.40)

0.114

1.41 (0.84–2.36)

0.194

 Delirium during ICU stay^c, n (%)

68 (19.3)

97 (27.6)

1.59 (1.17–2.26)

0.01

1.66 (1.21–2.26)

0.001

 One-year all-cause mortality^c, (%)

177 (50.3)

125 (35.5)

0.54 (0.40–0.74)

 < 0.001

0.64 (0.50–0.81)

 < 0.001

 Length of ICU stay (days) ^d, median (IQR)

3.3 [1.9, 7.6]

4.9 [2.4, 10.3]

0.91 (0.45–1.47)

 < 0.001

/

/

 Length of hospital stay (days) ^d, median (IQR)

7.2 [3.0, 16.6]

10.7 [5.6, 21.0]

2.87 (1.70–4.06)

 < 0.001

/

/

 Length of invasive mechanical ventilation (hours)^d, median (IQR)

25.0 [10.0, 61.2]

30.0 [15.0, 94.2]

6.0 (2.99–10.00)

 < 0.001

/

/

 Craniectomy^c, n (%)

38 (10.8)

27 (7.7)

0.69 (0.41–1.15)

0.155

0.73 (0.24–2.23)

0.58

 Tracheostomy^c, n (%)

51 (14.5)

85 (18.5)

1.88 (1.28–2.76)

0.001

2.07 (1.96–4.50)

0.045