Table 1 Overview of preclinical studies on stem cell therapy for dementia in Transgenic mouse models
From: Stem cell therapy use in patients with dementia: a systematic review
Cell Class | Murine embryonic NSCs (20) | Human foetal NSCs (21–23) | Human UCB-MSCs (24) | ||
|---|---|---|---|---|---|
Transgenic Mice Model | B6C3-Tg (APPswe/PSEN1dE9)(20) | NSE-APPswe (21) | Tg2576 (APPswe) (22) | 3×Tg-AD, CaM/Tet-DTA (23) | APP/PS1 (24) |
Stereotactic Injection Type | Bilateral intra-hippocampal | Bilateral intraventricular | Bilateral intra-hippocampal | Bilateral intra-hippocampal | Three bilateral intra-hippocampal |
Outcomes | Improved spatial memory (Morris water maze) Decreased expression of pro-inflammatory cytokines | Improved spatial memory (Morris water maze) Decreased expression of pro-inflammatory cytokines | Improved spatial memory (Morris water maze) | Improved spatial memory (Morris water maze, context- and place-dependent NOR task) | Improved spatial memory (Morris water maze) Reduced levels of pro-inflammatory cytokines |
Mechanism | Modulation of inflammation | - Modulation of inflammation - Microglia immune response - Protection from Aβ neurotoxicity | Neurotrophic support of endogenous neurogenesis and synaptic connectivity | Neurotrophic support of endogenous neurogenesis and synaptic connectivity | - Modulation of inflammation - Microglia -Anti-amyloidogenic |